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2 edition of Synthesis, crystallography and biological activity of myo-inositol phosphates. found in the catalog.

Synthesis, crystallography and biological activity of myo-inositol phosphates.

Ian David Spiers

Synthesis, crystallography and biological activity of myo-inositol phosphates.

by Ian David Spiers

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Published by Aston University.Department of Pharmaceutical and Biological Sciences in Birmingham .
Written in English


Edition Notes

Thesis (PhD) - Aston University, 1996.

ID Numbers
Open LibraryOL13843799M

  PA synthesis uses the 6-carbon myo-inositol as a backbone, which can be acquired externally (Klepek et al., ; Schneider et al., ) or synthesized de novo via conversion of glucosephosphate to d-inositolphosphate mediated by d-myo-inositolphosphate synthases (MIPSs) in plants (Loewus and Loewus, ).Cited by:   Design and synthesis of inhibitors of VC. Initially, OEG IP5, a low molecular weight derivative of the chelator previously used by our group to stabilize calcium phosphate nanoparticles for Cited by: 1.

  The biological activity and crystal structure of (±)-1,,5-di-O-isopropylidene-3,6-di-O-(2-propylpentanoyl)-myo-inositol have been investigated. This compound shows better anticonvulsant activity than valproic acid (VPA) in the MES test as measured in mice. Its structure, determined from single-crystal X-ray diffraction measurements, shows that the . Biological Crystallography ISSN High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy Raj Gill, Fiyaz Mohammed, Rajji Badyal, Leighton Coates, Peter Erskine, Darren Thompson, Jonathan Cooper, Michael Gore and Stephen Wood* Biomolecular Sciences Group, School of.

@article{osti_, title = {Synthesis, crystal, and biological activity of a novel carbene silver(I) complex with imidazole derivative}, author = {Jiu-Fu, Lu and Hong-Guang, Ge and Juan, Shi}, abstractNote = {Reaction of 2-(1-methyl-1,2-dihydroimidazolyl)acetonitrile tetrafluoroborate with silver oxide in dichloromethane readily yields [Ag(DIM){sub 2}]BF{sub 4}, . Diphosphoinositol polyphosphates (inositol pyrophosphates, X-InsP 7) are a family of second messengers with important roles in eukaryotic chemical synthesis and modification remains a challenging task due to the high density of phosphate groups arranged around the myo-inositol , a novel approach is presented that facilitates the incorporation of the Cited by: 5.


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Synthesis, crystallography and biological activity of myo-inositol phosphates by Ian David Spiers Download PDF EPUB FB2

Synthesis, crystallography and biological activity of myo-inositol phosphates the synthesis of myo-inositol 3-phosphate has been achieved in only 4 steps from myo-inositol.

The stereoselective addition of the chiral phosphorylating agent (2R,4S,5R)chloro-3,4-dimethylphenyl-1,3,2-oxazaphospholidinone to a protected inositol Author: Ian D. Spiers. Synthesis, crystallography and biological activity of myo-inositol phosphates. (Thesis) Spiers ID.

Publisher: University of Aston in Birmingham [] Metadata Source: The British Library Type: Thesis. Abstract: Highlight Terms No biological terms identified. Synthesis, crystallography and biological activity of myo-inositol phosphates.

By I.D Spiers. Abstract. SIGLEAvailable from British Library Document Supply Centre-DSC:DXN / BLDSC - British Library Document Supply CentreGBUnited KingdoAuthor: I.D Spiers.

The synthesis of naturally occurring myo-inositol phosphates and their synthetic derivatives is covered. In particular, the efforts to find agonists and antagonists of the most prominent inositol phosphate, myo-inositol-l,4,5-trisphosphate [Ins(1,4,5)P 3], are summarized, including some of their biochemical properties.

Finally, some of the most Cited by: 4. Arlen W. Frank, in Chemistry of Plant Phosphorus Compounds, Synthesis. Phosphorylation of myo-inositol with phosphoric acid/phosphorus pentoxide at °C yields a mixture of myo-inositol polyphosphates (n = ) from which phytic acid can be isolated by fractional crystallization of the barium yield is only 8%.

Alternatively, myo-inositol. The "other" inositols and their phosphates: synthesis, biology, and medicine (with recent advances in myo-inositol chemistry) Mark P. Thomas, Stephen J.

Mills, Barry V. Potter Department of Pharmacy & PharmacologyCited by: Annual Review of Plant Biology The Biosynthesis and Metabolism of Cytokinins D S Letham, and and L M S Palni Annual Review of Plant Physiology INOSITOL PHOSPHATE BIOCHEMISTRY Philip W.

Majerus Annual Review of Biochemistry Metabolism and Function of myo-Inositol and Inositol Phospholipids Bruce J. Holub Annual Review of NutritionCited by: The length of the diether linker was optimized to 3 methylenes by synthesis of DSB analog with 3, 4, 5 and 6 methyle95 and by comparison of their biological activit97 to DSB The synthesized C7-linked dimers have not Cited by: The membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) is an important regulator in cell physiology.

Hydrolysis of PtdIns(4,5)P2 by phospholipase C (PLC) releases two second messengers, Ins(1,4,5)P3 and diacylglycerol. To dissect the effects of PtdIns(4,5)P2 from those resulting from PLC-generated signals, a metabolically stabilized Cited by: The route for the synthesis of the desired compounds 3a-d is illustrated in Scheme ole dimers in the first steps of the synthesis were observed.

To increase the yields of the compound 2a and 2b and decrease the yields of dimers excessive α,ω-dibromoalkanes were used. The yields of the compound 2a and 2b were 56% and 60% respectively.

All crude products 3a-3d Author: Da-Hua Shi, Wei Min, Meng-qiu Song, Xin-Xin Si, Ming-Cheng Li, Zhao-yuan Zhang, Yu-Wei Liu, Wei-Wei. Phosphorofluoridate analogues, of myo-inositol 1,4,5-tris(phosphate), 4-and 5-phosphorofluoridate and 4,5-bis(phosphorofluoridate), were prepared and their biological acivity towards InsP 3 5-phosphatase was found to be similar to or more activ than that for InsP 3 while they proved to be less active in the binding assay than InsP by: 5.

The high affinity of adenophostin A for 1d-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] receptors may be related to an alteration in the position of its 2‘-phosphate group relative to the corresponding 1-phosphate group in Ins(1,4,5)P3. To investigate this possibility, two bicyclic trisphosphates 9 designed to explore the effect of relocating the 1-phosphate group Cited by: We describe a novel biosynthetic pathway for glycerophosphoinositides in Rhodothermus marinus in which inositol is activated by cytidine triphosphate (CTP); this is unlike all known pathways that involve activation of the lipid group instead.

This work was motivated by the detection in the R. marinus genome of a gene with high similarity to CTP:L-myo-inositolphosphate. Using cell-free extracts of M.

smegmatis mc(2), little activity was obtained with myo-inositol, 1D-myo-inositol 1-phosphate, or myo-inositol 2-phosphate as the N-acetylglucosamine acceptor. myo-Inositol is the physiologically most common tereoisomer and is abundantly (but not universally) distributed throughout much of the biological system.

myo -Inositol is an essential polyol in eukaryotes, where its phospholipid derivative phosphatidylinositol (PI) is an important constituent of phospholipid membranes.

Further examples for their numerous biological activities can be found in other chapters of this volume.

Unfortunately, however, frequently many of these molecules are only accessible with difficulties in minute amounts from scarce natural sources Author: P. Andersch, M. Berger, B. Jakob, K. Lange, M. Schneider. verted D-glucose 6-phosphate to 1-D-myo-inositol 3-phos-phate, the rate-limiting step for de novo inositol biosynthesis.

Activity of the recombinant human MIP synthase purified from Escherichia coli was optimal at pH at 37 °C and exhibited K m values of mM and 8 M for glucose 6-phosphate and NAD, respectively. Synthesis, characteristics and biological activity of pentacoordinated spirophosphoranes derived from amino acids Article in Amino Acids 28(4).

Free Online Library: Synthesis, Crystal Structure and Biological Activity of A Novel-Thidiazole Compound.(Report) by "Journal of the Chemical Society of Pakistan"; Chemistry Azo compounds Chemical properties Composition Production processes Chemical synthesis Methods Crystal structure Research Crystals.

Essentials of Glycobiology. This book explains the following topics: General Principles, Saccharide Structure and Nomenclature, Evolution of Glycan Diversity, Protein Glycan Interactions, Exploring the Biological Roles of Glycans, Biosynthesis, Metabolism, and Function, N Glycans, Proteoglycans and Glycosaminoglycans, Nuclear and Cytoplasmic Glycosylation.

Winning hemoglobin's heart: The synthesis of myo‐inositol tetrakisphosphates and bispyrophosphates yields a number of compounds that bind to hemoglobin and induce enhanced oxygen release.

These effects were analyzed in order to gain insight into structure–activity. ALTHOUGH myo-inositol hexakisphosphate (InsP6; phytate) is the most abundant inositol phosphate in nature1 and probably has a wide variety of functions2–8, neither the route of its synthesis.Introduction to Glycolysis.

This lecture note covers the following topics: Glycolysis is Energy Conversion, Glyceraldehyde Phosphate Dehydrogenase, Phosphoglycerate Kinase, Phosphoglycerate Mutase, Enolase, Net Reaction, Maintaining Redox Balance, NAD + Binding, Control of Glycolysis, Gluconeogenesis, Formation of Phosphoenopyruvate, Oxaloacetate Shuttle, High-Energy Phosphate .